Hidenori Endo

This study uses long-read multi-omics sequencing to analyze DNA-to-RNA remodeling in recurrent astrocytoma, identifying patient-specific genetic and epigenetic changes and their impact on RNA isoforms and protein fate.

This study develops a multiscale circulation model of cerebral hemodynamics to simulate flow redistribution in the Circle of Willis under normal, anatomical variation, and stenosis conditions, revealing key collateral pathway activation patterns.

This study identifies ALKBH1 as a driver of codon-biased translation and tumor microenvironment remodeling in glioma, promoting stemness and immune evasion.

This paper maps whole-brain directional neural information flow during auditory and visual naming using intracranial EEG, showing transient excitatory flows and their association with speech processing and stimulation-induced symptoms.

This study identifies staged translational remodeling in mouse cortex after ischemic stroke, showing changes in codon usage, ribosome occupancy, and frame-disruption events not captured by transcriptomics.

This paper constructs a dynamic causal white matter atlas of auditory and visual speech networks using intracranial data from 125 patients, revealing millisecond-scale coactivation patterns linked to speech naming tasks.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

The paper visualizes functional and effective connectivity in white matter networks during auditory descriptive naming tasks, showing how phrase order influences neural dynamics.

This study uses two-photon microscopy to show that T2DM impairs collateral circulation and increases leukocyte adhesion after ischemic stroke, leading to poor recovery and worse outcomes.

This study identifies altered monocyte subsets and suppressed interferon signaling in T2DM mice, contributing to worsened stroke outcomes through immunosuppression and inflammation.

The paper shows that tRNA modifications influence tissue-specific mRNA translation and codon optimization by analyzing tRNA and mRNA data from seven mouse tissues.