Atsushi Kanoke

Multiscale modeling of blood circulation with cerebral autoregulation and network pathway analysis for hemodynamic redistribution in the vascular network with anatomical variations and stenosis conditions

This study develops a multiscale circulation model of cerebral hemodynamics to simulate flow redistribution in the Circle of Willis under normal, anatomical variation, and stenosis conditions, revealing key collateral pathway activation patterns.

Connectome-based prediction of functional impairment in experimental stroke models

The paper predicts functional impairment in stroke models by analyzing connectivity changes and their relationship to motor and spatial memory function in rat brains.

Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke

This study uses two-photon microscopy to show that T2DM impairs collateral circulation and increases leukocyte adhesion after ischemic stroke, leading to poor recovery and worse outcomes.

Defective interferon signaling in the circulating monocytes of type 2 diabetic mice

This study identifies altered monocyte subsets and suppressed interferon signaling in T2DM mice, contributing to worsened stroke outcomes through immunosuppression and inflammation.