Keerthi Krishnan

CDKL5 deficiency results in atypical subregion-specific expression of perineuronal nets during mouse visual critical period

This study examines PNN expression in the V1 of CDKL5-deficient mice during the visual critical period, finding increased and subregion-specific PNN expression compared to controls.

Multidimensional analysis of a social behavior identifies regression and phenotypic heterogeneity in a female mouse model for Rett syndrome

The paper identifies two distinct behavioral phenotypes in a female mouse model of Rett syndrome using multidimensional analysis and DeepLabCut, showing age- and context-dependent regression.

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome

The paper identifies age-dependent changes in MECP2 expression and associated behavioral and cellular phenotypes in a female mouse model of Rett syndrome.

Lateralized expression of cortical perineuronal nets during maternal experience is dependent on MECP2

The paper shows maternal experience induces lateralized changes in perineuronal net density in adult female mice, dependent on MECP2.

Maternal experience-dependent cortical plasticity in mice is circuit- and stimulus-specific and requires Mecp2

This study shows that maternal experience-induced cortical plasticity in mice is circuit- and stimulus-specific, and requires Mecp2, with disrupted PV+ interneurons in Mecp2 mutants.

MECP2 regulates cortical plasticity underlying a learned behavior in adult female mice

This study shows that MECP2 is required for adult auditory cortical plasticity and retrieval learning in mice, with mutations impairing these processes and increasing inhibitory markers.