Z. Josh Huang

The paper introduces six novel gene knock-in mouse lines to label and study molecularly defined cortical intratelencephalic neuron subtypes with distinct projection patterns.

Fate mapping in mouse shows two separate MGE radial glia pools; the later pool uses temporal cohorts of fate-restricted basal intermediate progenitors to amplify and diversify cortical interneurons.

This study identifies a cortical circuit in mice that coordinates oromanual food manipulation through specific neuron types and their projections.

The paper identifies two neurogenic pathways, dNG-ETd and iNG-ETi, that differentially shape the organization and diversification of cortical output channels in mice.

The paper shows that motor cortical circuits integrate distorted proprioceptive feedback by separating activity subspaces to maintain task-relevant movement output.

The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.

The paper introduces CellREADR, an RNA sensor-effector technology for targeting and manipulating specific human cortical neuron types, validated through histological, electrophysiological, and transcriptomic methods.

The paper introduces CellREADR, an RNA-based technology for targeting and manipulating animal cells by coupling RNA sensing with effector protein translation, and provides a detailed experimental protocol for its implementation.

The paper shows that GABAergic input from chandelier cells tunes the axon initial segment of pyramidal neurons to maintain homeostatic plasticity.

The paper shows that intermediate progenitors generate projection neuron types in a non-sequential manner, challenging the inside-out model of cortical layering.

The paper identifies a corticothalamic channel in the motor cortex that coordinates skilled motor sequences by amplifying thalamic integration of sensorimotor inputs.

The paper uses genetic fate mapping in mice to show how direct and indirect neurogenesis contribute differently to the diversity and connectivity of glutamatergic projection neurons in the cerebral cortex.

This study shows that Dscam overexpression in Down syndrome mouse models causes excessive GABAergic inhibition of neocortical pyramidal neurons.

The paper identifies distinct functional subnetworks in the mouse cortex driven by two types of glutamatergic projection neurons during behavior.

This paper introduces CellREADR, a programmable RNA sensing technology that detects and manipulates cell types via RNA editing, demonstrating its use in mouse and human brain tissues.

Genetic or HF-rTMS activation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration after spinal cord injury.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper creates a comprehensive atlas of mouse primary motor cortex cell types using integrated transcriptomic and epigenomic data from over 600,000 samples.

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

The paper introduces a hybrid deep learning architecture combining topological priors with encoder-decoder networks to improve semantic segmentation of neuroanatomical data with high precision and recall.

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.

The paper develops genetic tools to dissect glutamatergic neuron subpopulations and their developmental trajectories in the cerebral cortex.

This study shows that maternal experience-induced cortical plasticity in mice is circuit- and stimulus-specific, and requires Mecp2, with disrupted PV+ interneurons in Mecp2 mutants.

The paper introduces BARseq, a method for high-throughput mapping of neuronal projections in the mouse auditory cortex, revealing novel projection types in specific cell subtypes.

Before eye opening, retinal and callosal activity regulates the density of chandelier cells in V1 to establish binocular vision.

The paper explores the diversity of GABAergic interneurons and proposes a framework for understanding their communication properties through transcriptional signatures.

This study identifies lineage programs in radial glial progenitors that generate striosome and matrix compartments through distinct intermediate progenitors, revealing their role in striatal circuit organization.

The paper introduces MetaNeighbor, a framework to assess cell type replicability across scRNA-seq datasets and identifies replicable neuronal subtypes with robust marker genes.

The paper uses genetic labeling and high-resolution microscopy to reveal fine-grained subtypes of cortical interneurons in mice, showing distinct connectivity patterns.