Daniel A. Louiselle

A comprehensive bulk and single-cell transcriptional atlas of pediatric leukemias

This study presents a comprehensive bulk and single-cell transcriptional dataset of 69 pediatric leukemia patients, demonstrating its utility in improving leukemia characterization and clinical testing.

Rapid and scalable preclinical evaluation of personalized antisense oligonucleotide therapeutics using organoids derived from rare disease patients

This paper describes a platform for generating patient-derived organoids to evaluate personalized antisense oligonucleotide therapeutics for rare diseases, showing reversal of disease phenotypes in Duchenne muscular dystrophy models.

Neonatal hyperoxia induces sex-dependent pulmonary cellular and transcriptomic changes in an experimental mouse model of bronchopulmonary dysplasia

This study investigates sex-dependent molecular and cellular changes in mouse lungs exposed to hyperoxia, identifying distinct progenitor and reparative responses in males and females.

Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes

The paper presents diagnostic analyses of 960 pediatric rare disease families using genomic sequencing and machine learning, finding higher diagnostic rates with long-read sequencing and highlighting challenges in variant interpretation.