Tau-induced elevation in promoter-proximal RNA polymerase II pausing is linked to decreased expression of long neuronal genes in a Drosophila tauopathy model.
Kendall Cottingham, Nima Goodarzi, David Fries, Geethma Lirushie, Hana Hall
The paper investigates how pathological tau affects gene expression in a Drosophila tauopathy model, finding increased RNA polymerase II pausing linked to reduced expression of long neuronal genes.
Frontiers in Aging Neuroscience · Sep 14, 2026Peer-reviewedMolecular Biology