Author

Xiaochu Zhao

Hospital for Sick ChildrenORCID 0000-0002-0875-3133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Berge Arakel MinassianiD· 2 shared Felix NitschkéiD· 2 shared Peixiang WangiD· 2 shared Saija AhoneniD· 2 shared Ami M. Perri· 1 shared Cameron A. Ackerley· 1 shared Dikran Richard GuissoiD· 1 shared Erin E. ChowniD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Berge Arakel MinassianORCID

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2 papers

Recent·Most cited

Gys1 antisense therapy rescues neuropathological bases of murine Lafora disease

Saija Ahonen, Silvia Nitschke, Tamar R. Grossman, Holly B. Kordasiewicz, Peixiang Wang, Xiaochu Zhao, Dikran Richard Guisso, Sahba Kasiri, Felix Nitschké, Berge Arakel Minassian

This study shows that Gys1 antisense therapy reduces Lafora body formation and neuroinflammation in mouse models of Lafora disease.

Brain · May 14, 2021Peer-reviewedNeuroscience

Deficiency of the E3 Ubiquitin Ligase RBCK1 Causes Diffuse Brain Polyglucosan Accumulation and Neurodegeneration

Mitchell Anthony Sullivan, Felix Nitschké, Erin E. Chown, Laura F. DiGiovanni, Mackenzie Chown, Ami M. Perri, Sharmistha Mitra, Xiaochu Zhao, Cameron A. Ackerley, Lori Israelian, Saija Ahonen, Peixiang Wang, Berge Arakel Minassian

This study shows that RBCK1 deficiency in mice leads to brain polyglucosan accumulation and neurodegeneration, similar to Lafora disease but with distinct regional and subcellular features.

bioRxiv · Mar 6, 2018 · PreprintMolecular Biology