Author

Sharmistha Mitra

The University of Texas Southwestern Medical CenterORCID 0000-0002-7259-1482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Berge Arakel MinassianiD· 2 shared Felix NitschkéiD· 2 shared Ami M. Perri· 1 shared Brandy Verhalen· 1 shared Cameron A. Ackerley· 1 shared Dikran Richard GuissoiD· 1 shared Emrah GumusgoziD· 1 shared Erin E. ChowniD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Berge Arakel MinassianORCID

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2 papers

Recent·Most cited

Targeting Gys1 with AAV-SaCas9 decreases pathogenic polyglucosan bodies and neuroinflammation in Adult Polyglucosan Body and Lafora disease mouse models

Emrah Gumusgoz, Dikran Richard Guisso, Sahba Kasiri, Jun Wu, Matthew Dear, Brandy Verhalen, Silvia Nitschke, Sharmistha Mitra, Felix Nitschké, Berge Arakel Minassian

This study uses AAV-delivered CRISPR/Cas9 to target Gys1 in mouse models of neurodegenerative diseases, reducing polyglucosan bodies and neuroinflammation.

Neurotherapeutics · Apr 1, 2021Peer-reviewedNeuroscience

Deficiency of the E3 Ubiquitin Ligase RBCK1 Causes Diffuse Brain Polyglucosan Accumulation and Neurodegeneration

Mitchell Anthony Sullivan, Felix Nitschké, Erin E. Chown, Laura F. DiGiovanni, Mackenzie Chown, Ami M. Perri, Sharmistha Mitra, Xiaochu Zhao, Cameron A. Ackerley, Lori Israelian, Saija Ahonen, Peixiang Wang, Berge Arakel Minassian

This study shows that RBCK1 deficiency in mice leads to brain polyglucosan accumulation and neurodegeneration, similar to Lafora disease but with distinct regional and subcellular features.

bioRxiv · Mar 6, 2018 · PreprintMolecular Biology