Systematic and quantitative analyses of pre-clinical Mycobacterium avium Lung Disease Tools for Drug Development and Transition from Animal Models to New Approach Methodologies
Moti Lal Chapagain, Devyani Deshpande, Shashikant Srivastava, Tawanda Gumbo
The paper benchmarks preclinical tools for Mycobacterium avium lung disease drug development, finding significant variability in PK/PD target attainment and recommending HFS-MAC for antibiotic ranking and translational studies.
bioRxiv · Jul 10, 2025 · PreprintPharmacology & Toxicology