Devyani Deshpande

Tigecycline pharmacodynamics in the hollow fiber system of Mycobacterium avium-complex lung disease, and the utility of MICs and time-kill studies in drug development

The paper evaluates tigecycline pharmacodynamics in MAC lung disease using time-kill studies and hollow fiber systems, finding EC50 values and suggesting inhaled tigecycline as a potential treatment.

Systematic and quantitative analyses of pre-clinical Mycobacterium avium Lung Disease Tools for Drug Development and Transition from Animal Models to New Approach Methodologies

The paper benchmarks preclinical tools for Mycobacterium avium lung disease drug development, finding significant variability in PK/PD target attainment and recommending HFS-MAC for antibiotic ranking and translational studies.