Uwe Ohler

SSMART identifies sequence-structure motifs for RNA-binding proteins by integrating sequence and structural preferences from RNA targets.

The paper investigates transcription initiation directionality in metazoans, finding species-specific sequence asymmetry and independent initiation events at promoters and enhancers.

ssHMM identifies sequence-structure motifs for RNA-binding proteins using a hidden Markov model and Gibbs sampling, outperforming existing tools in accuracy and speed.

The paper introduces omniCLIP, a Bayesian model for identifying protein-RNA interactions from CLIP-Seq data, applicable across different sequencing protocols.

The paper classifies human coding and non-coding genes based on RNA metabolism profiles, revealing distinct metabolic patterns and functional subsets of lncRNAs.

RiboTaper identifies actively translated open reading frames using spectral analysis of Ribo-seq data, revealing novel ORFs and validating peptide products in HEK293 cells.