Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice
Matt J. Matrongolo, Phillip S. Ang, Junbing Wu, Aditya Jain, Joshua K. Thackray, Akash Reddy, Chi-Chang Sung, Gaëtan Barbet, Young‐Kwon Hong, Max A. Tischfield
This study shows that Yoda1, a Piezo1 agonist, reduces intracranial pressure and improves CSF flow and meningeal lymphatic function in craniosynostosis and aged mice.
Journal of Clinical Investigation · Nov 2, 2023Peer-reviewedNeuroscience