Lucas Vicuña

The paper generates a single-cell transcriptional atlas of Indigenous South American populations and shows genetic ancestry influences immune gene expression, particularly after stimulation.

The paper develops a joint statistical model to show that higher Mapuche genetic ancestry and accelerating BMI trajectories independently increase the likelihood of early menarche in admixed girls.

The paper identifies genetic variants associated with pubertal stage transitions and BMI using joint models in a Latino cohort, finding 43 novel associations and links between Native American ancestry and earlier Tanner 2 stage onset in boys.

This study uses genomic data to analyze the recent population history of the Mapuche, finding shared ancestry with Southern Patagonia and Central Chile populations, a population bottleneck around 1650 AD, and post-admixture adaptation in Chileans.

This study conducts GWAS on BMI and related traits in admixed Chilean children, identifying genetic variants associated with BMI and age at adiposity rebound, and highlighting differences by Native American ancestry.