Author

John A. Cooper

Washington University in St. LouisORCID 0000-0002-0933-4571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

James D. DeBrechtiD· 2 shared Olivia L. MooreniD· 2 shared Patrick McConnell· 2 shared Benjamin C. StarkiD· 1 shared Bo HuiD· 1 shared Diane S. SepichiD· 1 shared Fang Hua LiniD· 1 shared Jimann ShiniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

James D. DeBrechtORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Alzheimer's Disease-associated gene CD2AP regulates permeability of endothelial cells and transendothelial migration of immune cells

Michael D. Onken, John A. Cooper

This study shows that CD2AP regulates endothelial barrier function and immune cell transmigration, linking it to Alzheimer's disease.

bioRxiv · Oct 4, 2026 · PreprintCell Biology

Biochemical Functions of the Membrane-Binding Domain of CARMIL

Olivia L. Mooren, Patrick McConnell, James D. DeBrecht, John A. Cooper

This study investigates the biochemical functions of the MB domain of CARMIL, showing it targets proteins to membranes, activates CP, and enhances actin assembly.

Journal of Biological Chemistry · Apr 22, 2026Peer-reviewedBiochemistry

Reconstitution of Arp2/3-Nucleated Actin Assembly with CP, V-1 and CARMIL

Olivia L. Mooren, Patrick McConnell, James D. DeBrecht, Mahapatra Anshuman Jaysingh, John A. Cooper

The paper investigates whether CPI-motif proteins activate or inhibit Arp2/3-mediated actin assembly by reconstituting the system with purified components and finds that CARMIL promotes actin assembly by counteracting V-1 inhibition.

Current Biology · Oct 21, 2024Peer-reviewedCell Biology

CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish

Benjamin C. Stark, Yuanyuan Gao, Diane S. Sepich, Lakyn Belk, Matthew A. Culver, Bo Hu, Marlene J. Mekel, Wyndham Ferris, Jimann Shin, Lilianna Solnica‐Krezel, Fang Hua Lin, John A. Cooper

This study shows that CARMIL3 is essential for endodermal cell migration and morphogenesis during zebrafish embryogenesis, affecting Kupffer's vesicle formation and left/right asymmetry.

Developmental Biology · Sep 30, 2021Peer-reviewedDevelopmental Biology