Real-time imaging of rotation during synthesis by the replisome
Thomas M Retzer, Lional Rajappa, Masateru Takahashi, Samir M. Hamdan, Karl E. Duderstadt
The paper uses real-time imaging to study replisome rotation during DNA synthesis, finding that high-speed rotation supports continuous synthesis but reduces processivity and increases polymerase numbers.
Science Advances · Jan 1, 2026Peer-reviewedBiophysics