Differential BUM-HMM: a robust statistical modelling approach for detecting RNA flexibility changes in high-throughput structure probing data
Paolo Marangio, Ka Ying Toby Law, Guido Sanguinetti, Sander Granneman
This paper introduces diffBUM-HMM, a statistical model for detecting RNA flexibility changes in high-throughput structure probing data, showing higher sensitivity and fewer false positives than existing methods.
Genome biology · May 27, 2021Peer-reviewedSystems Biology