Author

Ka Ying Toby Law

McLean HospitalORCID 0000-0002-6582-6124Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:human· 1

Frequent Co-Authors

A.A. MacdonaldiD· 1 shared Alexandre A. LussieriD· 1 shared Christopher M. PalmeriD· 1 shared Guido SanguinettiiD· 1 shared Javier Gilbert‐JaramilloiD· 1 shared Junghyup SuhiD· 1 shared Kerry James RessleriD· 1 shared Malvina MilletiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

A.A. MacdonaldORCID

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2 papers

Recent·Most cited

Acute Ethanol Exposure Induces Stage-Specific Bioenergetic, Mitochondrial and Neurodevelopmental Transcriptional Remodeling in Human Forebrain Progenitors

Oluwarotimi O. Folorunso, Alexandre A. Lussier, A.A. Macdonald, Ka Ying Toby Law, Malvina Millet, Junghyup Suh, Kerry James Ressler, Christopher M. Palmer, Javier Gilbert‐Jaramillo

This study shows that acute ethanol exposure causes stage-specific transcriptional changes in human forebrain progenitors, affecting mitochondrial and bioenergetic genes differently in early versus late progenitors.

bioRxiv · May 29, 2026 · PreprintNeuroscience

Differential BUM-HMM: a robust statistical modelling approach for detecting RNA flexibility changes in high-throughput structure probing data

Paolo Marangio, Ka Ying Toby Law, Guido Sanguinetti, Sander Granneman

This paper introduces diffBUM-HMM, a statistical model for detecting RNA flexibility changes in high-throughput structure probing data, showing higher sensitivity and fewer false positives than existing methods.

Genome biology · May 27, 2021Peer-reviewedSystems Biology