A multimodal foundation model linking histopathology and DNA methylation
Dianyu Wang, Jessica Zhang, Chen Chen, Wei Zhang, Song Wang, Yanda Meng, Guru Sonpavde, Craig Horbinski, Yu Tian
HistoMethyl links histopathology with DNA methylation to predict molecular features from H&E slides alone, improving mutation prediction and survival outcomes across multiple cancer cohorts.
bioRxiv · Jun 14, 2026 · PreprintCancer Biology