Craig Horbinski

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

This study evaluates the efficacy of KL-50 and its combination with belinostat in IDHmut gliomas, showing enhanced cytotoxicity in MMR-deficient models and potential mechanisms involving DNA repair pathways and PKMYT1.

This study creates a mouse model of IDH-mutant 1p/19q-codeleted oligodendroglioma and identifies genotype-specific phenotypes and molecular features.

This study analyzes a diverse glioma cohort to show ancestry influences on survival, somatic alterations, and mutational processes in diffuse gliomas.

HistoMethyl links histopathology with DNA methylation to predict molecular features from H&E slides alone, improving mutation prediction and survival outcomes across multiple cancer cohorts.

This study evaluates a bispecific T cell-engaging antibody in immunocompetent GBM models, showing improved survival, TME remodeling, and immune memory induction.

This study identifies genetic changes in IDH-mutant gliomas that correlate with treatment response and tumor evolution using longitudinal genomic data from 206 patient samples.

The paper develops and validates a CNS-specific library and analysis platform using the COMET(TM) system for high-dimensional proteomic multiplex imaging of the central nervous system.