Dirk Fasshauer

Heimdall SNAREs reveal an ancestral architecture of eukaryotic SNARE complexes

The paper characterizes SNARE-like proteins from Heimdallarchaeota, showing their four-helix bundle structure and evolutionary relationship to eukaryotic SNARE complexes.

TRACEY: an updated resource for SNARE protein domain annotation with improved HMMs and expanded sequence coverage

TRACEY updates SNARE protein domain annotation with improved HMMs and expanded sequence coverage, improving domain detection across species.

Transmembrane domain composition reflects subcellular localization of SNARE proteins

The paper analyzes SNARE transmembrane domains to show how their composition adapts to different membrane environments, with early pathway SNAREs having more Phe and late pathway SNAREs having more Ile.

Rapid and Interpretable Protein Contact Map Prediction Using a Pattern-Matching Strategy

The paper introduces a pattern-matching strategy to predict protein contact maps from sequences, achieving high correlation with experimental data using minimal computational resources.

A look beyond the QR code of SNARE proteins

The paper investigates the structural arrangement of SNARE proteins in QabcR complexes and shows that structural exchange is tolerated but some non-cognate exchanges lead to imbalances.

Unveiling Conserved Allosteric Hot Spots in Protein Domains from Sequences

The paper develops a sequence-based method to create 2D contact maps and analyze conserved allosteric hot spots in protein domains without requiring GPUs.

Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors

The paper identifies SNARE and related vesicle trafficking factors in giant viruses, suggesting they may hijack host trafficking mechanisms for replication.

High cell diversity and complex peptidergic signalling underlie placozoan behaviour

This study identifies diverse peptidergic signaling in placozoans, revealing cell-type-specific neuropeptide expression and behavioral responses that suggest peptidergic signaling predates synapses in nervous system evolution.