Luciano A. Abriata

The paper provides validated 1H,15N backbone assignments for commercial hen egg white lysozyme at natural 15N abundance and demonstrates their utility in various applications.

This paper computationally designs light-responsive proteins that undergo conformational changes upon light activation, enabling precise control of biological functions.

This study designs metamorphic proteins that switch between multiple conformations and shows how mutations can shift their conformational equilibrium.

AF3 Inspector provides an interactive web tool to visualize and analyze all AlphaFold 3 structural models, addressing limitations in the official service.

This paper introduces LDDM, a generative model for drug design that produces synthetically accessible compounds validated experimentally for five protein targets.

This study demonstrates the ability to detect and discriminate microcystin congeners at sub-nanomolar concentrations using aerolysin nanopores, with applications for environmental monitoring.

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

This study reveals how β-lactam antibiotics interact with the histidine kinase VbrK through redox-dependent cysteine acylation, enabling bacterial resistance.

This study identifies and characterizes nonlinear ion transport phenomena in β-barrel nanopores, linking lumen charge distribution to open-pore rectification and gating.

This study investigates how cardiolipin dynamics influence mitochondrial membrane remodeling via OPA1 interactions using molecular dynamics and cryoEM.

This paper designs phosphorylation-induced protein switches that control transcription in cells, demonstrating their functionality in synthetic signaling.

This paper designs light-regulated dynamic proteins using deep learning, showing precise optogenetic control of cellular processes.

This study identifies ACAD10 and ACAD11 as enzymes critical for metabolizing 4-hydroxy fatty acids in mammals, revealing their unique mechanisms and subcellular localization.

The paper presents high-resolution cryo-EM structures of aerolysin pre-pore and pore in a membrane-like environment, revealing key interactions and constriction rings relevant for nanopore sensing.

The paper investigates the structural arrangement of SNARE proteins in QabcR complexes and shows that structural exchange is tolerated but some non-cognate exchanges lead to imbalances.

This study investigates how posttranslational modifications affect the membrane interaction and helical structure of the N-terminal fragment of the huntingtin protein.

HandMol provides an immersive, collaborative molecular modeling tool using WebXR, AI, and HCI technologies, enabling natural interactions and real-time collaboration without specialized software.

PeSTo predicts protein interacting interfaces using a parameter-free geometric transformer that acts on atom labels, outperforming existing methods and enabling analysis of dynamic structural data.

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.

The paper proposes a structural model of Cyc2, an outer membrane protein in Acidithiobacillus ferrooxidans, as a modular cytochrome-β-barrel fusion protein based on computational methods and functional insights.