The Pro- vs. Anti-Angiogenic Capacity of Short Chain Fatty Acids is Dependent on the Bioavailability of FFAR3 in Peripheral Artery Disease.
Sivaraman Kuppuswamy, Kripa Patel, Wenbo Zhi, Vijay Chaitanya Ganta
This study shows SCFAs promote angiogenesis in PAD by activating FFAR3, while Palmitate impairs it, and FFAR3 loss blocks SCFA benefits.
bioRxiv · Feb 20, 2025 · PreprintPathology