Biomechanics of stem cell fate decisions in multilayered tissues
Preeti Sahu, Sara Monteiro-Ferreira, Sara Canato, Raquel Maia Soares, Adriana Sánchez‐Danés, Édouard Hannezo
This study develops a 3D vertex-based model to show how mechanical forces and spatial competition influence stem cell fate decisions in skin epidermis, linking cell shape to clonal dynamics in basal cell carcinoma.
Nature Communications · Sep 26, 2025Peer-reviewedBiophysics