Édouard Hannezo

The paper identifies two progenitor cell populations in mouse urethra with distinct self-renewal patterns and sex-specific differences in epithelial dynamics.

The paper shows Yap mechanotransduction creates a self-limiting feedback loop for zebrafish semicircular canal formation, integrating mechanical forces and transcriptional responses to ensure robust development.

This study shows that substrate disorder promotes single-cell cancer invasion, comparable to cadherin loss, by altering invasion dynamics through spatial heterogeneity.

The paper identifies a mechano-chemical feedback mechanism in Drosophila epithelial cells that maintains junction length and shape stability through differential turnover of apicobasal regulators.

The paper identifies how cell heterogeneity and YAP1 inactivation drive tissue patterning during intestinal regeneration through feedback mechanisms.

The paper shows mechanical feedback alone can stabilize stem cell populations in tissues without needing adhesion or niche signals.

This study shows that geometric confinement affects ERK signaling and collective migration in epithelial tissues by altering mechanical states through actomyosin contractility.

The paper shows keratins balance spreading forces and tissue resilience in zebrafish embryos to enable uniform tissue spreading.

The paper investigates how scaling of signaling pathways affects adult organ regeneration, finding that mismatched scaling of SHH and Wnt9a signaling prevents digit regeneration in large blastemas.

The paper shows that optimal collective migration in heterogeneous tissues occurs at intermediate adhesion strength, validated through vertex models and zebrafish experiments.

This study shows that early zebrafish embryo geometry guides asymmetric cell divisions and patterns zygotic genome activation, influencing cell cycle timing and developmental robustness.

The paper shows that meroblastic cleavage in zebrafish embryos involves a two-step process with mechanical uncoupling and cadherin-mediated adhesion, distinct from canonical cytokinesis.

This study shows cancer cells follow intrinsic self-organized programs that coordinate tumor cell state transitions during growth, revealing mechanical gradients and stereotyped patterns of heterogeneity and plasticity.

This study shows cells exhibit complex migration patterns along haptotactic gradients, including oscillations and directed movement, and develops a biophysical model to explain these behaviors.

This study develops a 3D vertex-based model to show how mechanical forces and spatial competition influence stem cell fate decisions in skin epidermis, linking cell shape to clonal dynamics in basal cell carcinoma.

This study introduces a theoretical framework for self-organized chemotaxis in heterogeneous cell populations and validates it with in vitro experiments on immune cell co-migration.

The paper shows that stochastic division timing and cell mechanics contribute to robust embryo patterning and morphogenesis in mammals.

The paper shows that vertebral segmentation during axolotl tail regeneration occurs via a buckling instability mechanism, distinct from the somite-based process in embryonic development.

The paper studies BMP signalling dynamics in the developing neural tube, showing temporal relay mechanisms drive self-organised cell type patterns.

The paper uses lineage tracing and mathematical modeling in zebrafish to show that heterogeneous progenitor decisions establish a precise BEC-to-hepatocyte ratio and drive postembryonic liver growth.

The paper investigates how cell cycle dynamics influence the fluidity of the developing mouse neuroepithelium, revealing a glass transition mechanism rather than a jamming transition.

The paper shows how a Nodal/TGF-β morphogen gradient coordinates pattern-preserving tissue morphogenesis in zebrafish gastrulation through motility-driven (un)jamming transitions.

The paper identifies a self-generated Toddler gradient guided by Aplnr that directs mesodermal cell migration during zebrafish gastrulation.

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.

The paper shows that hyaluronate pressure, driven by local secretion and anisotropic tissue stiffness, shapes zebrafish semicircular canals without actomyosin contractility.

The paper shows how cell fate-specific changes in osmotic and actomyosin forces coordinate robust organoid morphogenesis through lumen volume reduction and mechanical tension.