NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to Low-Voltage-Fast onset seizures in Dravet syndrome.
Fabrizio Capitano, Mathieu Kuchenbuch, Jennifer Lavigne…·Massimo Mantegazza
The paper investigates seizure mechanisms in Dravet syndrome, finding that preictal dysfunctions of inhibitory interneurons lead to rebound hyperactivity and low-voltage-fast seizures.