Steve I. Perlmutter

Volitional control of a recurrent brain computer interface via covert reinforcement of endogenous reward networks

This study shows rats can control a brain-computer interface using covert reinforcement by stimulating their own reward networks, enabling precise neural signal modulation without external rewards.

Mechanically Compliant, Precision-Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Brain-stiffness-matched pHEMA/GMA hydrogel scaffolds with 40 µm interconnected pores reduced astrocyte encapsulation and iNOS+ macrophage fraction versus stiff solid rods after 4 weeks in rat brain.

Spinal cord population activity lacks rotational dynamics during an alternating isometric task in macaque

The paper shows that spinal cord activity in macaques lacks rotational dynamics during an alternating isometric task, unlike motor cortex activity.

Local field potentials and single unit dynamics in motor cortex of unconstrained macaques during different behavioral states

The paper analyzes neural dynamics in macaque motor cortex across behavioral states using LFP and spike data, finding distinct frequency band patterns and coupling during different states.

Responses of cortical neurons to intracortical microstimulation in awake primates

This study examines how cortical neurons in awake primates respond to intracortical microstimulation, revealing complex dynamics including excitatory responses and inhibitory periods.

Serotonergic Modulation of Spinal Circuitry Restores Motor Function after Chronic Spinal Cord Injury

This study combines serotonergic agonist delivery with rehabilitation to improve motor recovery in severely injured rats, showing long-term benefits after treatment cessation.

Movement-Dependent Electrical Stimulation for Volitional Strengthening of Cortical Connections in Behaving Monkeys

This study shows that movement-gated electrical stimulation combined with repeated movement use strengthens motor-cortical connections in monkeys, supporting use-dependent rehabilitation for injury recovery.

Paired stimulation for spike-timing dependent plasticity quantified with single neuron responses in primate motor cortex

The paper quantifies spike-timing dependent plasticity (STDP) in primate motor cortex using paired stimulation and single neuron responses, finding that potentiation occurs only when the second stimulus precedes the response.

Cortical inhibitory network selects cerebellar signals for movement initiation

The paper investigates how cerebellar signals are selected for movement initiation through inhibitory network dynamics in the motor cortex.

Cortical responses to vagus nerve stimulation are modulated by brain state in non-human primates

This study examines how brain state affects cortical responses to vagus nerve stimulation in non-human primates, finding that certain components of the response vary with brain state and stimulation frequency.

Comparative Neuroanatomy of the Lumbosacral Spinal Cord of the Rat, Cat, Pig, Monkey, and Human

This paper creates a high-resolution MRI atlas of the lumbosacral spinal cord across five species to guide spinal cord research and clinical applications.