Author

Ke Si

First Affiliated Hospital of Guangzhou Medical UniversityORCID 0000-0002-1168-5979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Cheng WuiD· 1 shared D. Z. Li· 1 shared Haipeng ZhuiD· 1 shared Ningning Sun· 1 shared Shuai MaoiD· 1 shared Weiling Liang· 1 shared Wenliang ZhangiD· 1 shared Zehang JiangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Cheng WuORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintAug 19, 2026

Divergent malignant evolution converges on shared immunosuppressive ecosystems through tumor-intrinsic TMED2-ADAR1-dependent complement signalling in multifocal hepatocellular carcinoma

Cheng Wu, Ke Si, Shuai Mao…·Wenliang Zhang

This study identifies shared immunosuppressive mechanisms in multifocal hepatocellular carcinoma despite divergent tumor evolution, highlighting a TMED2-ADAR1-C3/C5 complement axis as a potential therapeutic target.

DOI 10.64898/2026.04.21.719788

humanscRNA-seq

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