Sigrid Le Clerc

HaploExplore detects MiA-haploblocks, offering a novel approach for studying genetic associations and complex traits by focusing on minor allele haploblocks.

This paper evaluates models for predicting tissue of origin from circulating DNA by comparing features of fragmentation around TSSs and the tissue specificity of lncRNAs versus coding genes.

The paper analyzes gene expression in chronic chikungunya patients and controls to identify differentially expressed genes and pathways associated with long-term effects of infection.

The paper reanalyzes genomic data from HIV-1 Elite Controllers to identify MHC-associated SNPs and HLA alleles, revealing haploblock effects and novel mechanisms for EC.