Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands
Amber Vogel, Alan Blakely, Yuankun Dao, Nai-Pin Lin, Danny Hung‐Chieh Chou, Christopher P. Hill
The paper explains how bivalent insulin receptor ligands act as antagonists or agonists based on the order of their binding sites, using cryo-EM structures.
bioRxiv · Aug 23, 2025 · PreprintMolecular Biology