Christopher P. Hill

This paper uses a protein language model to classify AAA family proteins by their mechanistic function, showing that sequence context can predict biochemical mechanisms.

The paper identifies a divergent cytochrome c in malaria parasites with an unusually low redox potential, suggesting a novel biochemical role outside the canonical electron transport chain function.

The paper explains how bivalent insulin receptor ligands act as antagonists or agonists based on the order of their binding sites, using cryo-EM structures.

This study investigates Vps4p's substrate binding and the mechanism linking substrate recruitment to autoinhibition release using peptide binding assays.

The paper presents structures of AFPKs from Elysia chlorotica, revealing the ACP linker's role in regulating substrate and product selectivity during polyketide and fatty acid synthesis.

This study shows that mutations preventing phosphorylation of BMP4's prodomain impair its proteolytic activation in homodimers, causing lethality in mice.