Sympathetic Nerve Activity Promotes Cardiomyocyte Cell-Cycle Arrest And Binucleation
Li Chen, Alexander Y. Payumo, Kentaro Hirose, Rachel B. Bigley, Jonathan Lovas, Rejji Kuruvilla, Guo N. Huang
This study shows that sympathetic nerve activity reduces cardiomyocyte proliferation and causes binucleation, which may limit heart regeneration in adults.
bioRxiv · Apr 5, 2017 · PreprintDevelopmental Biology