Predicting Pre-treatment Resistance or Post-treatment Effect? A Systematic Benchmarking of Single-Cell Drug Response Models
Li Shen, Xinliang Sun, Shuyu Zheng, Ali Hashmi, Johanna Eriksson, Harri K. Mustonen, Hanna Seppänen, Bairong Shen, Min Li, Markus J. V. Vähä-Koskela, Jing Tang
This study benchmarks single-cell drug response models across 26 datasets, showing performance varies with dataset type, imbalance, and model design, with scDEAL showing competitive results.
bioRxiv · May 10, 2026 · PreprintBioinformatics