Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery
Daniel Domingo‐Fernándéz, Yojana Gadiya, Abhishek Patel, Sarah Mubeen, Daniel Rivas-Barragan, Chris W. Diana, Biswapriya B. Misra, David Healey, Joe Rokicki, Viswa Colluru
RPath prioritizes drugs for diseases by analyzing causal paths in knowledge graphs using drug-perturbed and disease-specific transcriptomic signatures, outperforming existing methods.
PLoS Computational Biology · Feb 25, 2022Peer-reviewedBioinformatics