Dmitry Biba

gnomAD v4 (730,947 exomes) brings LOFTEE-2 loss-of-function annotation (0.90 precision, strict mode), missense-aware constraint, and LLM-mined literature evidence combined with constraint to rank disease genes.

The paper models prokaryotic antivirus defense strategies and finds that immunity is preferred at high viral pressure and PCD at low host population size, with potential antagonism from overinvestment in immunity.

This study uses mathematical modeling to show that optimal strategies for balancing somatic damage repair and asymmetric allocation depend on extrinsic mortality and damage accumulation rates, linking these to the evolutionary r/K selection theory.