Co-administration of simvastatin mitigates clozapine-induced lifespan extension and mitochondrial functional recovery in Drosophila melanogaster.
Katherine R. H. Mortimer, Jacob Reed, Nicoleta Moisoi, Melissa Mather, Mohammad Zia Ul Haq Katshu, Reinhard J. Stöger, Lisa Chakrabarti
This study shows that simvastatin reduces clozapine-induced lifespan extension and mitochondrial recovery in Drosophila, suggesting a trade-off between mitochondrial adaptation and health outcomes.
bioRxiv · Oct 24, 2026 · PreprintPhysiology