Ludovico Calabrese

This study identifies two homeostatic mechanisms in mammalian cells that regulate dry mass and volume to maintain a target density during proliferation.

The paper develops a mechanistic model of bacterial growth that incorporates amino acid pools, ppGpp sensing, and transcriptional regulation, showing oscillatory dynamics during environmental changes.

The paper constructs a quantitative model of biosynthesis to explain how mRNA levels, ribosomes, and RNA polymerase influence cell growth, and validates it against experimental observations in yeast and E. coli.

The paper shows that protein degradation balances ribosome allocation at slow growth, maintaining active ribosomes even as growth rate diminishes.