Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity.
Zeyu Zhu, Defne Surujon, Juan Cesar Federico Ortiz-Marquez, Stephen J. Wood, Wenwen Huo, Ralph R. Isberg, José Bento, Tim van Opijnen
This paper introduces transcriptomic entropy as a generalizable predictor of bacterial fitness and antibiotic sensitivity across species and stress conditions using RNA-Seq and experimental evolution data.
Nature Communications · Aug 31, 2020Peer-reviewedSystems Biology