Genetic and environmental imprints on T cell receptor repertoires as predictors of graft-versus-host disease
Assya Trofimov, Zachary Montague, Magdalena L Russell, Rachel Bender Ignacio, Terry Stevens‐Ayers, Danniel Zamora, Marco B. Mielcarek, Michael Boeckh, Frederick A. Matsen IV, Armita Nourmohammad
This study shows that donor T cell receptor repertoires are influenced by both HLA genetics and recent viral infections, with higher HLA heterozygosity and TCR-HLA coherence linked to increased GVHD risk.
bioRxiv · Dec 25, 2025 · PreprintImmunology