Zachary Montague

The paper analyzes T-cell receptor repertoires in individuals with and without post-acute sequelae of COVID-19 to identify immune signatures associated with PASC.

This study identifies design principles of cytotoxic CD8+ T-cell responses by modeling them as feedback-controlled programs, revealing trade-offs between infection clearance and immunopathology, and suggesting strategies for improving T-cell therapies.

This study shows that donor T cell receptor repertoires are influenced by both HLA genetics and recent viral infections, with higher HLA heterozygosity and TCR-HLA coherence linked to increased GVHD risk.

The paper introduces a formalism to analyze co-evolutionary arms races between immune systems and pathogens, showing how information exchange rates and entropy production can identify leaders and followers, and defines co-evolutionary efficiency as a metric for information exploitation.