Author

Karolina Ewa Zakrzewska

Institute of Fundamental Technological ResearchORCID 0000-0002-1346-2445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Jarosław WalczakiD· 2 shared Karol NienałtowskiiD· 2 shared Michał KomorowskiiD· 2 shared Agata BraniewskaiD· 1 shared Christina Maria Wagner· 1 shared Edyta Głów· 1 shared Jan RehwinkeliD· 1 shared Piotr Topolewski· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSystems Biology

Jarosław WalczakORCID

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2 papers

Recent·Most cited

Single-cell profiling quantifies the dose gap between population-average and complete pY-STAT1/3 suppression by JAK inhibitors

Karolina Ewa Zakrzewska, Jarosław Walczak, Karol Nienałtowski, Piotr Topolewski, Christina Maria Wagner, Agata Braniewska, Tomasz P. Rygiel, Richard Moriggl, Michał Komorowski

The paper quantifies the discrepancy between population-average and single-cell suppression of pY-STAT1/3 by JAK inhibitors, showing that strong average suppression leaves many cells with elevated responses.

bioRxiv · Oct 28, 2026 · PreprintSystems Biology

Fractional response analysis reveals logarithmic cytokine responses in cellular populations

Karol Nienałtowski, Rachel E. Rigby, Jarosław Walczak, Karolina Ewa Zakrzewska, Edyta Głów, Jan Rehwinkel, Michał Komorowski

This paper introduces fractional response analysis to quantify single-cell signaling responses and finds cytokine responses scale logarithmically with dose.

Nature Communications · Jul 7, 2021Peer-reviewedSystems Biology