Jan Rehwinkel

This study identifies XRN1 as a key regulator of HDV infection, showing it controls viral replication through dsRNA homeostasis and innate immune activation.

This study shows that HIF activation limits pneumovirus replication by enhancing innate immune sensing and reducing viral RNA methylation.

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

This study identifies Annexin A2 as a critical mediator of RIG-I-like receptor responses to viral infection by promoting MDA5 oligomerization and enhancing interferon production.

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

This study shows that SMG6-dependent NMD prevents dsRNA accumulation and immunogenicity in HCC by maintaining dsRNA homeostasis and suppressing MHC-I-presented peptides.

The paper identifies reduced EXOSC2 expression as protective against SARS-CoV-2 infection and clinical COVID-19 by inhibiting viral replication and upregulating antiviral genes.

This study uses in vivo CRISPR screening to identify SAGA complex members as key regulators of hematopoiesis, showing their loss impairs blood production and activates interferon pathways.

This paper introduces fractional response analysis to quantify single-cell signaling responses and finds cytokine responses scale logarithmically with dose.