Michał Komorowski

Single-cell profiling quantifies the dose gap between population-average and complete pY-STAT1/3 suppression by JAK inhibitors

The paper quantifies the discrepancy between population-average and single-cell suppression of pY-STAT1/3 by JAK inhibitors, showing that strong average suppression leaves many cells with elevated responses.

Fractional response analysis reveals logarithmic cytokine responses in cellular populations

This paper introduces fractional response analysis to quantify single-cell signaling responses and finds cytokine responses scale logarithmically with dose.

Channel Capacity Computations for Unregulated and Autoregulated Gene Expression

This study quantifies information transfer fidelity in gene expression models, showing transcriptional control has higher capacity than translational control, and feedback reduces overall capacity.