Spatiotemporal Proteome Remodeling Directs Human Hematopoietic Stem Cells via a Metabolic-Cytoskeletal Axis
Zahra Taghadomi Masoumi, Navin Shirodkar, Lauren Wheeler, Megan Guthrie, Daniel Davies, Diana Hernandez, William E. Grey
The paper maps proteomic and spatial changes in human HSCs during ex vivo expansion, identifying a metabolic-cytoskeletal axis that coordinates structural polarity and organelle reorganization.
bioRxiv · Jun 10, 2026 · PreprintCell Biology