Author

Megan Guthrie

University of YorkORCID 0009-0007-1456-4818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

William E. GreyiD· 2 shared Alexandra Y. KreinsiD· 1 shared Amanda Thomaz· 1 shared Andrew B. FieldingiD· 1 shared Andrew D. Bates· 1 shared Andrew S. FarriD· 1 shared Anna A. Straatman-IwanowskaiD· 1 shared Antonella F. M. DostiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

William E. GreyORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 10, 2026

Spatiotemporal Proteome Remodeling Directs Human Hematopoietic Stem Cells via a Metabolic-Cytoskeletal Axis

Zahra Taghadomi Masoumi, Navin Shirodkar, Lauren Wheeler…·William E. Grey

The paper maps proteomic and spatial changes in human HSCs during ex vivo expansion, identifying a metabolic-cytoskeletal axis that coordinates structural polarity and organelle reorganization.

DOI 10.64898/2026.06.08.728414

humanproteomics

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Cancer BiologybioRxivSep 18, 2025

Moonlighting Role of Meiotic SYCP1 in Breast Cancer: A Chromatin-Bound Regulator of DNA Repair, Transcription, and Drug Resistance

Urszula Lucja McClurg, Wee-Wei Tee, Owen Richard Davies…·Andrew B. Fielding

This study identifies SYCP1 as a chromatin-bound regulator in breast cancer that promotes DNA repair, transcription, and drug resistance, with clinical implications for prognosis and therapy.

DOI 10.1126/sciadv.aea2067

humanproteomics

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Cell BiologybioRxivPreprintSep 15, 2025

WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells

Jessica C. Orr, Elizabeth K. Haughey, Andrew S. Farr…·Robert E. Hynds

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

1 citation

humanscRNA-seq

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