High-Throughput Single-Molecule R-loop Footprinting Reveals Principles of R-loop Formation
Maika Malig, Stella R. Hartono, Jenna M. Giafaglione, Lionel A. Sanz, Frederic L. Chedin
The paper develops SMRF-seq to profile R-loops with high resolution and shows they form from unspliced transcripts at genic hotspots, influenced by DNA sequence and topology.
Journal of Molecular Biology · Mar 1, 2020Peer-reviewedGenetics