Lionel A. Sanz

This study shows that RNase H1 is critical for mitochondrial genome maintenance in B cells but has little effect on nuclear R-loops.

The paper introduces TRIPn-Seq to identify transcription-replication interactions in mouse B cells, finding they correlate with replication stress and genomic instability.

This study shows that the S9.6 antibody binds RNA rather than RNA:DNA hybrids in fixed cells, leading to unreliable imaging data.

This study shows that SF3B1 inhibition causes intron retention and R-loop changes, with R-loop gains linked to stress-response gene readthrough and not DNA damage.

The paper develops SMRF-seq to profile R-loops with high resolution and shows they form from unspliced transcripts at genic hotspots, influenced by DNA sequence and topology.

This study shows DNA Topoisomerase I regulates R-loop formation by causing gains and losses at different genomic regions, affecting replication and cell cycle progression.