Alvaro A. Beltran

The paper assesses regulatory activity of cortical structure-associated variants using MPRA in human neural progenitor cells, identifying 918 variants with regulatory potential and showing condition-dependent effects.

This study shows that C9orf72 repeat expansions alter chromatin loops in neurons, linking RNA-DNA interactions to gene dysregulation in ALS.

The paper links early cell cycle gene expression in cortical organoids to interindividual variability in infant brain growth trajectories.

This study shows that human cortical organoids generated across multiple sites using a harmonized protocol consistently produce similar cell types and structures, though with some site-specific differences in size and stress markers.

Segmentor is a tool for manual refinement of 3D microscopy annotations, improving efficiency without sacrificing accuracy.