Author

Gautham Dharuman

Argonne National LaboratoryORCID 0000-0002-1472-1947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Amin Tavakoli· 1 shared Animashree AnandkumariD· 1 shared Arvind RamanathaniD· 1 shared Frances H. ArnoldiD· 1 shared Jason YangiD· 1 shared Matthew Hill· 1 shared Sukhvinder KauriD· 1 shared Théophile LambertiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Amin Tavakoli

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintAug 30, 2025

Sequence-Based Generative AI-Guided Design of Versatile Tryptophan Synthases

Théophile Lambert, Amin Tavakoli, Gautham Dharuman…·Frances H. Arnold

This paper uses a generative AI model to design novel tryptophan synthase variants with enhanced catalytic activity and substrate promiscuity, outperforming natural and optimized versions.

DOI 10.1101/2025.08.30.673177

E. coliprotein sequence

𝕏 PostBluesky