David C. Clarke

This study uses mathematical modeling to investigate the multifactorial causes of anabolic resistance in sarcopenia and evaluates therapeutic strategies to restore muscle protein metabolism.

This study identifies distinct lncRNA expression profiles in skeletal muscle after aerobic and resistance exercise using RNA-seq data.

This study uses a bioinformatic network inference algorithm to identify causal signaling networks regulating RPS6KB1 expression in response to aerobic and resistance exercise in human skeletal muscle.

This study shows endurance training improves lysosomal biogenesis factors in aged rat skeletal muscle, counteracting age-related sarcopenia and enhancing muscle function.

The paper develops a kinetic model of leucine-mediated mTOR signaling and protein metabolism in human skeletal muscle, showing that basal p70S6K levels determine MPS and insulin signaling affects net protein balance.

The paper develops a mathematical model of AMPK signaling dynamics in skeletal muscle during exercise and finds that ADP, not AMP, is the dominant controller of AMPK activity due to its higher concentration.