Author

Ian F. Coccimiglio

Simon Fraser UniversityORCID 0000-0001-7194-7750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:rat· 1

Frequent Co-Authors

David C. ClarkeiD· 2 shared Ashok NarasimhaniD· 1 shared Brendon J. GurdiD· 1 shared Cristina Rodríguez‐RodrígueziD· 1 shared Fabio M V RossiiD· 1 shared Gang Chen· 1 shared Kassia Régnier· 1 shared Keitaro YamanouchiiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

David C. ClarkeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJun 2, 2026

Pathology-Targeted EP4 Agonism Reverses Fibrosis in a Rat Model of DMD

Nasim Kajabadi, Ashok Narasimhan, Gang Chen…·Fabio M V Rossi

This study shows that Irodanoprost, a bone-targeted EP4 agonist, reduces fibrosis and restores muscle regeneration in a rat model of Duchenne muscular dystrophy.

DOI 10.64898/2026.05.29.728674

ratexperimental assay

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BioinformaticsGenesPeer-reviewedJan 20, 2026

Bioinformatic analysis of differentially expressed long non-coding RNAs in skeletal muscle following aerobic and resistance exercise

Kassia Régnier, Lucas P. R. Beaupre, Ian F. Coccimiglio…·Brendon J. Gurd

This study identifies distinct lncRNA expression profiles in skeletal muscle after aerobic and resistance exercise using RNA-seq data.

1 citation

humanbulk RNA-seq

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Systems BiologyPLoS Computational BiologyPeer-reviewedJul 30, 2020

ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise

Ian F. Coccimiglio, David C. Clarke

The paper develops a mathematical model of AMPK signaling dynamics in skeletal muscle during exercise and finds that ADP, not AMP, is the dominant controller of AMPK activity due to its higher concentration.

31 citations

humanstatistical model

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